Fermentation intricacies involving dairy milk and their bioactive, health, microbial, and product challenges: A terse review
Main Article Content
Keywords
fermentation practices; microbial entities; product development; raw milk; regulations
Abstract
Fermentation is widely applied to enhance the safety, stability, and functional properties of dairy milk as part of broader milk processing and hygiene controls. This concise review examines the intricacies of dairy milk fermentation, focusing on microbial activity, bioactive chemical aspects, and product quality/safety. Bioactive peptides derived from fermentation-driven acidification have been shown to kill bacteria, contain antioxidants, lower blood pressure, and modulate the immune system, thereby enhancing microbiological safety and shelf life. However, there are key aspects, from milk composition, through culture performance, to processing circumstances that can affect safety and uniformity. Besides, bioactive molecular characterization, indigenous starter culture confirmation, and probiotic efficacy are required to enhance the success of dairy milk fermentation. To ensure high-quality, safe, and stable fermented dairy products, the process of fermentation science and risk-based regulatory frameworks must not be overlooked. Moreso, enhanced regulations of fermentation technologies can guarantee process reproducibility, product safety, and maximal bioactivity.
References
Adewumi, G.A. 2019. Health-promoting fermented foods. In Melton, L., Shahidi, F., & Varelis, P. (Eds.), Encyclopedia of Food Chemistry (pp. 399–418). Academic Press. https://doi.org/10.1016/B978-0-08-100596-5.21774-5
Agyei, D., Pan, S., Acquah, C. and Danquah, M.K. 2017. Bioactivity profiling of peptides from food proteins. In Soft Chemistry and Food Fermentation. https://doi.org/10.1016/B978-0-12-811412-4.00003-5
Akbarian, M., Khani, A., Eghbalpour, S. and Uversky, V.N. 2022. Bioactive peptides: Synthesis, sources, applications, and proposed mechanisms of action. International Journal of Molecular Sciences 23(3): 1445. https://doi.org/10.3390/ijms23031445
Al Haj, O. A. and Al Kanhal, H. A. 2010. Compositional, technological and nutritional aspects of dromedary camel milk. International Dairy Journal 20: 811–821. https://doi.org/10.1016/j.idairyj.2010.04.003
Alavi, F., Salami, M., Emam-Djomeh, Z. and Mohammadian, M. 2017. Nutraceutical properties of camel milk. In Nutrients in Dairy and Their Implications for Health and Disease. https://doi.org/10.1016/B978-0-12-809762-5.00036-X
AL-Ayadhi, L. and Halepoto, D.M. 2017. Camel milk as a potential nutritional therapy in autism. In Nutrients in Dairy and Their Implications for Health and Disease. https://doi.org/10.1016/B978-0-12-809762-5.00030-9
Al-Dhaheri, A.S., Al-Hemeiri, R., Kizhakkayil, J., Al-Nabulsi, A., Abushelaibi, A., Shah, N.P. and Ayyash, M. 2017. Health-promoting benefits of low-fat akawi cheese made by exopolysaccharide-producing probiotic Lactobacillus plantarum isolated from camel milk. Journal of Dairy Science, 100(10): 7771–7779. https://doi.org/10.3168/jds.2017-12761
Alhassani, W.E. 2024. Camel milk: Nutritional composition, therapeutic properties, and benefits for human health. Open Veterinary Journal 14(12): 3164–3180.
Alonso-Amelot, M.E. 2018. Milk as a natural product: Foreign natural and anthropogenic organic compounds in it. In Studies in Natural Products Chemistry. https://doi.org/10.1016/B978-0-444-64058-1.00010-8
Altay, F. 2017. Rheology and functionality of ayran-a yogurt drink. In Yogurt in Health and Disease Prevention. https://doi.org/10.1016/B978-0-12-805134-4.00017-1
Alu’datt, M.H., Rababah, T., Alhamad, M.N., Obaidat, M.M., Gammoh, S., Ereifej, K., Al-Ismail, K., Althnaibat, R.M. Kubow, S. 2016. Evaluation of different drying techniques on the nutritional and biofunctional properties of a traditional fermented sheep milk product. Food Chemistry 190: 436–441. https://doi.org/10.1016/j.foodchem.2015.05.118
Anadón, A., Martínez-Larrañaga, M.R., Ares, I. and Martínez, M.A. 2017. Chapter 21—Overview: Preclinical studies of dairy milk and products on health. In Watson, R.R., Collier, R.J. and Preedy, V.R. (Eds.), Nutrients in Dairy and their Implications on Health and Disease (pp. 261–285). Academic Press. https://doi.org/10.1016/B978-0-12-809762-5.00021-8
Aouadhi, C., 2025. Comprehending the influence of enzyme sources, environmental parameters, and storage conditions on the proteolytic activity of cow milk. International Dairy Journal, p.106444.
Arihara, K., Zhou, L. and Ohata, M. 2017. Bioactive properties of Maillard reaction products generated from food protein-derived peptides. In Advances in Food and Nutrition Research. https://doi.org/10.1016/bs.afnr.2016.11.005
Asemi Z., Jazayeri, S., Najafi, M., Samimi, M., Mofid. V. and Shidfar F. 2011. Effects of daily consumption of probiotic yoghurt on inflammatory factors in pregnant women: A randomized controlled trial. Pakistan Journal of Biological Sciences 14: 476–482.
Ashenafi, M. 2006. A review on the microbiology of indigenous fermented foods and beverages of Ethiopia. Ethiopian Journal of Biological Sciences 5.2 (2006): 189–245.
Ayyash, M., Al-Nuaimi, A.K., Al-Mahadin, S. and Liu, S.Q. 2018. In vitro investigation of anticancer and ACE-inhibiting activity, α-amylase and α-glucosidase inhibition, and antioxidant activity of camel milk fermented with camel milk probiotic: A comparative study with fermented bovine milk. Food Chemistry 239: 588–597. https://doi.org/10.1016/j.foodchem.2017.06.149
Balasubramaniam, V.M., Martinez-Monteagudo, S.I. and Gupta, R. 2015. Principles and application of high pressure–based technologies in the food industry. Annual Review of Food Science and Technology 6: 435–462.
Barberis, S.E., Origone, A.L., Adaro, M.O. and Bersi, G. 2018. Chapter 5—Bioactive peptides as functional food ingredients. In Grumezescu, A.M. and Holban, A.M. (Eds.), Role of Materials Science in Food Bioengineering (pp. 147–186). Academic Press. https://doi.org/10.1016/B978-0-12-811448-3.00005-X
Basilicata, M.G., Pepe, G., Sommella, E., Ostacolo, C., Manfra, M., Sosto, G., Pagano, G., Novellino, E. and Campiglia, P. 2018. Peptidome profiles and bioactivity elucidation of buffalo-milk dairy products after gastrointestinal digestion. Food Research International 105: 1003–1010. https://doi.org/10.1016/j.foodres.2017.12.038
Behare, P., Lule, V.K. and Patil, P. 2016. Yogurt: dietary importance. In Caballero, B., Finglas, P.M. and Toldrá, F. (Eds.), Encyclopedia of Food and Health (pp. 612–616). Academic Press. https://doi.org/10.1016/B978-0-12-384947-2.00765-0
Beltrán-Barrientos, L.M., Estrada-Montoya, C., Reyes-Díaz, R., Hernández-Mendoza, A., González-Córdova, A.F. and Vallejo-Córdoba, B. 2018. Does gamma-aminobutyric acid have a potential role on the antihypertensive effect of fermented milk with Lactococcus lactis NRRL B-50571? Journal of Functional Foods 48: 297–301. https://doi.org/10.1016/j.jff.2018.07.016
Benkerroum, N. 2013. Traditional fermented foods of North African countries: Technology and food safety challenges with regard to microbiological risks. Comprehensive Reviews in Food Science and Food Safety 12.1(2013): 54–89.
Berhe, T., Ipsen, R., Seifu, E., Kurtu, M.Y., Eshetu, M. and Hansen, E.B. 2018. Comparison of the acidification activities of commercial starter cultures in camel and bovine milk. LWT—Food Science and Technology 89: 123–127. https://doi.org/10.1016/j.lwt.2017.10.041
Beukes, E.M., Bernie, H.B. and Johannes, F.M. 2001. The microbiology of South African traditional fermented milks. International Journal of Food Microbiology 63.3(2001): 189–197.
Bevilacqua, A., Sinigaglia, M., Corbo, M.R. 2016. Fermented foods: Origins and applications. In Caballero, B., Finglas, P.M. and Toldrá, F. (Eds.), Encyclopedia of Food and Health (pp. 675–680). Academic Press. https://doi.org/10.1016/B978-0-12-384947-2.00281-6
Bintsis, T. and Papademas, P. 2022. The evolution of fermented milks, from artisanal to industrial products: A critical review. Fermentation 8(12): 679. https://doi.org/10.3390/fermentation8120679
Bokulich, N.A., Amiranashvili, L., Chitchyan, K., Ghazanchyan, N., Darbinyan, K., Gagelidze, N., Sadunishvili, T., Goginyan, V., Kvesitadze, G., Torok, T. and Mills, D.A. 2015. Microbial biogeography of the transnational fermented milk matsoni. Food Microbiology 50: 12–19. https://doi.org/10.1016/j.fm.2015.01.018
Bourrie, B.C.T., Willing, B.P. and Cotter, P.D. 2016. The microbiota and health promoting characteristics of the fermented beverage kefir. Frontiers in Microbiology. 7, 196946, : 1–17.
Brenmoehl, J., Ohde, D., Wirthgen, E. and Hoeflich, A. 2018. Cytokines in milk and the role of TGF-beta. In Best Practice and Research: Clinical Endocrinology and Metabolism. https://doi.org/10.1016/j.beem.2018.01.006
Brück, W.M. Functional foods in infant formulae. Food Science and Technology Bulletin: Functional Foods 1.9(2005): 1–14.
Bucci, A.J., Van Hekken, D.L., Tunick, M.H., Renye, J.A. and Tomasula, P.M. 2018. The effects of microfluidization on the physical, microbial, chemical, and coagulation properties of milk. Journal of Dairy Science 101(8): 6990–7001. https://doi.org/10.3168/jds.2017-13907
Cadogan, J., Eastell, R., Jones, N. and Barker, M.E. 1997. Milk intake and bone mineral acquisition in adolescent girls: Randomised, controlled intervention trial. British Medical Journal 315:1255–1260. https://doi.org/10.1136/bmj.315.7118.1255
Carminati, D. and Tidona, F. 2017. Chapter 31—Nutritional value and potential health benefits of donkey milk. In Watson, R.R., Collier, R.J. and Preedy, V.R. (Eds.), Nutrients in Dairy and their Implications on Health and Disease (pp. 407–414). Academic Press. https://doi.org/10.1016/B978-0-12-809762-5.00031-0
Centers for Disease Control and Prevention. Raw milk. CDC, 2023. https://www.cdc.gov/food-safety/foods/raw-milk.html (Accessed: 05 January 2026).
Chai, K.F., Voo, A.Y.H. and Chen, W.N. Bioactive peptides from food fermentation: A comprehensive review of their sources, bioactivities, applications, and future development. Comprehensive Reviews in Food Science and Food Safety 2020;19:3825–3885. https://doi.org/10.1111/1541-4337.12651
Chan, C.L., Gan, R.Y., Shah, N.P. and Corke, H. 2018. Enhancing antioxidant capacity of Lactobacillus acidophilus-fermented milk fortified with pomegranate peel extracts. Food Bioscience 26: 185–192. https://doi.org/10.1016/j.fbio.2018.10.016
Chen G.W., Tsai J.S. and Pan B.S. Purification of angiotensin I-converting enzyme inhibitory peptides and antihypertensive effect of milk produced by protease-facilitated lactic fermentation. International Dairy Journal 2007;17:641–647. https://doi.org/10.1016/j.idairyj.2006.07.004.
Clark, S. and Mora García, M.B. 2017. A 100-year review: Advances in goat milk research. Journal of Dairy Science. https://doi.org/10.3168/jds.2017-13287
Costa, M.P. Da, Frasao, B.D.S., Lima, B.R.C. D.C., Rodrigues, B.L. and Junior, C.A.C. 2016. Simultaneous analysis of carbohydrates and organic acids by HPLC-DAD-RI for monitoring goat’s milk yogurts fermentation. Talanta 152: 162–170. https://doi.org/10.1016/j.talanta.2016.01.061
Da Silva, M.S. and Rudkowska, I. 2015. Dairy nutrients and their effect on inflammatory profile in molecular studies. Molecular Nutrition & Food Research 59:1249–1263. https://doi.org/10.1002/mnfr.201400569.
Danova, S., Nemska, V. and Tropcheva, R. 2017. Bulgarian yogurt-like product “Katak.” In Yogurt in Health and Disease Prevention. https://doi.org/10.1016/B978-0-12-805134-4.00018-3
de Melo Pereira, G.V., de Carvalho Neto, D.P., Maske, B.L., De Dea Lindner, J., Vale, A.S., Favero, G.R., ... and Soccol, C.R. 2022. An updated review on bacterial community composition of traditional fermented milk products: What next-generation sequencing has revealed so far? Critical Reviews in Food Science and Nutrition 62(7): 1870–1889.
de Moreno de LeBlanc, A., Luerce, T.D., Miyoshi, A., Azevedo, V. and LeBlanc, J.G. 2018. Chapter 7—Functional food biotechnology: The use of native and genetically engineered lactic acid bacteria. In Barh, D. and Azevedo, V. (Eds.), Omics Technologies and Bio-Engineering (pp. 105–128). Academic Press. https://doi.org/10.1016/B978-0-12-815870-8.00007-3
de Oliveira, M.N. 2014. Fermented milks: Fermented milks and yogurt. In Encyclopedia of Food Microbiology: Second Edition. https://doi.org/10.1016/B978-0-12-384730-0.00121-X
de Souza de Azevedo, P.O., Aliakbarian, B., Casazza, A.A., LeBlanc, J.G., Perego, P. and de Souza Oliveira, R.P. 2018. Production of fermented skim milk supplemented with different grape pomace extracts: Effect on viability and acidification performance of probiotic cultures. Pharma Nutrition https://doi.org/10.1016/j.phanu.2018.03.001
Dimidi E., Cox S.R., Rossi M., and Whelan K. 2022. Fermented foods: Definitions and characteristics, impact on the gut microbiota and effects on gastrointestinal health. Nat Rev Gastroenterol Hepatol 19:196–208. https://doi.org/10.1038/s41575-021-00547-5
Dirar, H. 1993. The indigenous fermented foods of the Sudan: A study in African food and nutrition. CABI ISBN 9780851988580. PP. 576.
Ebner, J., Aşçi Arslan, A., Fedorova, M., Hoffmann, R., Küçükçetin, A. and Pischetsrieder, M. 2015. Peptide profiling of bovine kefir reveals 236 unique peptides released from caseins during its production by starter culture or kefir grains. Journal of Proteomics 117: 41–57. https://doi.org/10.1016/j.jprot.2015.01.005
Elkhtab, E., El-Alfy, M., Shenana, M., Mohamed, A. and Yousef, A.E. 2017. New potentially antihypertensive peptides liberated in milk during fermentation with selected lactic acid bacteria and kombucha cultures. Journal of Dairy Science 100(12): 9508–9520. https://doi.org/10.3168/jds.2017-13150
Fantuz, F., Salimei, E. and Papademas, P. 2016. Macro- and micronutrients in non-cow milk and products and their impact on human health. In Non-Bovine Milk and Milk Products. https://doi.org/10.1016/B978-0-12-803361-6.00009-0
Farah, Z., Mollet, M., Younan, M. and Dahir, R. 2007. Camel dairy in Somalia: Limiting factors and development potential. Livestock Science 110(1–2): 187–191.
Fazilah, N.F., Ariff, A.B., Khayat, M.E., Rios-Solis, L. and Halim, M. 2018. Influence of probiotics, prebiotics, synbiotics and bioactive phytochemicals on the formulation of functional yogurt. Journal of Functional Foods 48: 387–399. https://doi.org/10.1016/j.jff.2018.07.039
Feng, C., Zhang, W., Zhang, T., Li, B., He, Q., Kwok, L.Y. and Zhang, H. 2022. Oral administration of pasteurized probiotic fermented milk alleviates dextran sulfate sodium-induced inflammatory bowel disease in rats. Journal of Functional Foods 94: 105140. https://doi.org/10.1016/J.JFF.2022.105140
Fernandez, M.A., Picard-Deland, Le Barz, M., Daniel, N. and Marette, A. 2016. Yogurt and Health. In Fermented Foods in Health and Disease Prevention. https://doi.org/10.1016/B978-0-12-802309-9.00013-3
Fernández, M., Hudson, J.A., Korpela, R. and de los Reyes-Gavilán, C.G. 2015. Impact on human health of microorganisms present in fermented dairy products: An overview. BioMed Research International 2015: 412714.
Food and Drug Administration (FDA) (2024a). “Grade ‘A’ Pasteurized Milk Ordinance.” FDA, 2023. https://www.fda.gov/food/milk-guidance-documents-regulatory-information/pasteurized-milk-ordinance-centennial (Accessed 16 April 2025).
Food and Drug Administration (FDA). (2024b). The dangers of raw milk: Unpasteurized milk can pose a serious health risk. Available at: https://www.fda.gov/food/buy-store-serve-safe-food/dangers-raw-milk-unpasteurized-milk-can-pose-serious-health-risk (Accessed: 16 April 2025).
Fox, P.F., Uniacke-Lowe, T., McSweeney, P.L.H. and O’Mahony, J.A. 2017. Dairy Chemistry and Biochemistry (2nd ed.). Springer.
Franco, I., Perez, M.D., Conesa, C., Calvo, M. and Sanchez, L. 2018. Effect of technological treatments on bovine lactoferrin: an overview. Food Research International 106:173–182. https://doi.org/10.1016/j.foodres.2017.12.016.
Freitas, M. 2017. Chapter 24—The benefits of yogurt, cultures, and fermentation. In Floch, M.H., Ringel, Y. and Walker, W.A. (Eds.), The Microbiota in Gastrointestinal Pathophysiology (pp. 209–223). Academic Press. https://doi.org/10.1016/B978-0-12-804024-9.00024-0
Fugl, A., Berhe, T., Kiran, A., Hussain, S., Laursen, M.F., Bahl, M.I., Hailu, Y., Sørensen, K.I., Guya, M.E., Ipsen, R. and Hansen, E.B. 2017. Characterisation of lactic acid bacteria in spontaneously fermented camel milk and selection of strains for fermentation of camel milk. International Dairy Journal 73: 19–24. https://doi.org/10.1016/j.idairyj.2017.04.007
Fusco V, Chieffi D, Fanelli F, et al. 2020. Microbial quality and safety of milk and milk products in the 21st century. Comprehensive Reviews in Food Science and Food Safety 19: 2013–2049.
Gagnaire, V. and Jan, G. 2017. Chapter 22—Proteomics of fermented milk products. In Colgrave, M.L. (Ed.), Proteomics in Food Science (pp. 361–382). Academic Press. https://doi.org/10.1016/B978-0-12-804007-2.00022-9
García-Burgos, M., Moreno-Fernández, J., María, J.M. Díaz-Castro, A.J. and López-Aliaga, I. 2020. New perspectives in fermented dairy products and their health relevance. Journal of Functional Foods 72: 104059. https://doi.org/10.1016/j.jff.2020.104059
Garcia-Gonzalez N., Battista N., Prete R., and Corsetti A. 2023. Health-promoting role of lactic acid bacteria in fermented dairy products. Microorganisms. 11(2):395. https://doi.org/10.3390/microorganisms9020349
Garcia-Montoya, I.A., Cendon, T.S., Ar-evalo-Gallegos, S. and Rascon-Cruz, Q. 2012. Lactoferrin a multiple bioactive protein: an overview. Biochimica et Biophysica Acta. 1820: 226–236. https://doi.org/10.1016/j.bbagen.2011.06.018.
Giacometti, J. and Buretić-Tomljanović, A. 2017. Peptidomics as a tool for characterizing bioactive milk peptides. Food Chemistry 230: 91–98. https://doi.org/10.1016/j.foodchem.2017.03.016
Gibson, M. and Newsham, P. 2018. Chapter 11—Milk and Dairy. In Gibson, M. and Newsham, P. (Eds.), Food Science and the Culinary Arts (pp. 133–167). Academic Press. https://doi.org/10.1016/B978-0-12-811816-0.00011-7
Givens, D.I. 2012. Milk in the diet: Good or bad for vascular disease? Proceedings of the Nutrition Society 71:98–104. https://doi.org/10.1017/S0029665111003223.
Griebler, U., Bruckmüller, M.U., Kien, C., Dieminger, B., Meidlinger, B. and Seper, K. 2016. Health effects of cow's milk consumption in infants up to 3 years of age: a systematic review and meta-analysis. Public Health Nutrition 19: 293–307. https://doi.org/10.1017/S1368980015001354.
Griffiths M.W. and Tellez A.M. 2013. Lactobacillus helveticus: The proteolytic system. Frontiers in Microbiology 4:30. https://doi.org/10.3389/fmicb.2013.00030
Gul, O., Mortas, M., Atalar, I., Dervisoglu, M. and Kahyaoglu, T. 2015. Manufacture and characterization of kefir made from cow and buffalo milk, using kefir grain and starter culture. Journal of Dairy Science 98(3): 1517–1525. https://doi.org/10.3168/jds.2014-8755
Guo, L., Qian, J.P., Guo, Y.S., Hai, X., Liu, G.Q., Luo, J.X. and Ya, M. 2018. Simultaneous identification of bovine and equine DNA in milks and dairy products inferred from triplex TaqMan real-time PCR technique. Journal of Dairy Science 101(8): 6776–6786. https://doi.org/10.3168/jds.2018-14408
Hadjimbei, E., Botsaris, G. and Chrysostomou, S. 2022. Beneficial effects of yoghurts and probiotic fermented milks and their functional food potential. Foods 11(17): 2691. https://doi.org/10.3390/foods11172691
Hafeez, Z., Cakir-Kiefer, C., Roux, E., Perrin, C., Miclo, L. and Dary-Mourot, A. 2014. Strategies of producing bioactive peptides from milk proteins to functionalize fermented milk products. In Food Research International. https://doi.org/10.1016/j.foodres.2014.06.002
Hansen, E.B. 2018. Redox reactions in food fermentations. In Current Opinion in Food Science. https://doi.org/10.1016/j.cofs.2018.03.004
Hazlett, R., Schmidmeier, C. and O’Mahony, J.A. 2019. Milk proteins. In Melton, L., Shahidi, F. and Varelis, P. (Eds.), Encyclopedia of Food Chemistry (pp. 138–147). Academic Press. https://doi.org/10.1016/B978-0-08-100596-5.21604-1
He, J., Wofford, M.R., Reynolds, K., Chen, J., Chen, C.S. and Myers, L. 2011. Effect of dietary protein supplementation on blood pressure: A randomized, controlled trial. Circulation 124:589–595. https://doi.org/10.1161/CIRCULATIONAHA.110.009159
Hill, C., Guarner, F., Reid, G., Gibson, G.R., Merenstein, D.J., Pot, B., Morelli, L., Canani, R.B., Flint, H.J., Salminen, S. and Calder, P.C., 2014. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nature reviews Gastroenterology & hepatology, 11(8), pp.506-514.
Hill, D., Ross, R.P., Arendt, E. and Stanton, C. 2017b. Microbiology of yogurt and bio-yogurts containing probiotics and prebiotics. In Yogurt in Health and Disease Prevention. https://doi.org/10.1016/B978-0-12-805134-4.00004-3
Hill, D., Sugrue, I., Arendt, E., Hill, C., Stanton, C. and Ross, R.P. 2017a. Recent advances in microbial fermentation for dairy and health. F1000Research 6.
How, Y.H., Teo, M.Y.M., In, L.L.A., Yeo, S.K. and Pui, L.P. 2022. Development of fermented milk using food-grade recombinant Lactococcus lactis NZ3900. NFS Journal, 28: 1–14. https://doi.org/10.1016/J.NFS.2022.07.001
Huang, G., Chen, S., Tang, Y., Dai, C., Sun, L., Ma, H. and He, R. 2018. Stimulation of low intensity ultrasound on fermentation of skim milk medium for yield of yoghurt peptides by Lactobacillus paracasei. Ultrasonics Sonochemistry 51: 315–324. https://doi.org/10.1016/j.ultsonch.2018.09.033
Huang, P., Yu, L., Tian, F., Zhao, J., Zhang, H., Chen, W. and Zhai, Q. 2022. Untargeted metabolomics revealed the key metabolites in milk fermented with starter cultures containing Lactobacillus plantarum CCFM8610. Lebensmittel-Wissenschaft & Technologie 165: 113768. https://doi.org/10.1016/J.LWT.2022.113768
Ismail, B. and Nielsen, S.S., 2010. Invited review: Plasmin protease in milk: Current knowledge and relevance to dairy industry. Journal of dairy science, 93(11), pp.4999-5009.
Iwasa, M. and Aoi, W. 2017. Benefits of lactobacillus helveticus fermented milk in sports and health. In Dairy in Human Health and Disease across the Lifespan. https://doi.org/10.1016/B978-0-12-809868-4.00013-3
Jang, H.J., Lee, N.K. and Paik, H.D. 2024. Overview of dairy-based products with probiotics: Fermented or non-fermented milk drink. Food Science of Animal Resources 44(2): 255.
Jangra, S., Sharma, R.K., Pothuraju, R. and Bhakri, G. 2019. Milk fermented with Lactobacillus casei NCDC19 improves high fat and sucrose diet alters gene expression in obese mice. International Dairy Journal 90: 15–22. https://doi.org/10.1016/j.idairyj.2018.11.002
John R.P., Nampoothiri K.M. and Pandey A. 2006. Solid-state fermentation for L-lactic acid production from agro wastes using Lactobacillus delbrueckii. Process Biochemistry 41:759–763. https://doi.org/10.1016/j.procbio.2005.09.013
Júnior, L.M., Anjos, C.A.R. and Cristianini, M. 2023. Food packaging for high-pressure thermal processing. In High Pressure Thermal Processing; Elsevier: Amsterdam, The Netherlands, pp. 269–289.
Kalyankar, S.D., Khedkar, C.D. and Patil, A.M. 2016. Goat: Milk. In Caballero, B., Finglas, P.M. and Toldrá, F. (Eds.), Encyclopedia of Food and Health (pp. 256–260). Academic Press. https://doi.org/10.1016/B978-0-12-384947-2.00358-5
Kanurić, K.G., Milanović, S.D., Ikonić, B.B., Lončar, E.S., Iličić, M.D., Vukić, V.R. and Vukić, D.V. 2018. Kinetics of lactose fermentation in milk with kombucha starter. Journal of Food and Drug Analysis 26(4): 1229–1234. https://doi.org/10.1016/j.jfda.2018.02.002
Kapila, R., Sharma, R. and Kapila, S. 2017. Milk and fermented milk products in alleviation of aging pathophysiology. In Dairy in Human Health and Disease across the Lifespan. https://doi.org/10.1016/B978-0-12-809868-4.00022-4
Kashung, P. and Karuthapandian, D., 2025. Milk-derived bioactive peptides. Food Production, Processing and Nutrition, 7(1), p.6. https://doi.org/10.1186/s43014-024-00280-2
Kavitake, D., Kandasamy, S., Devi, P.B. and Shetty, P.H. 2018. Recent developments on encapsulation of lactic acid bacteria as potential starter culture in fermented foods—A review. In Food Bioscience. https://doi.org/10.1016/j.fbio.2017.11.003
Khalesi, M., Salami, M., Moslehishad, M., Winterburn, J. and Moosavi-Movahedi, A.A. 2017. Biomolecular content of camel milk: A traditional superfood towards future healthcare industry. In Trends in Food Science and Technology. https://doi.org/10.1016/j.tifs.2017.02.004
Khaliq, A., Chughtai, M.F.J., Mehmood, T., Ahsan, S., Liaqat, A., Nadeem, M., Sameed, N., Saeed, K., Rehman, J.U. and Ali, A. 2021. High-pressure processing; Principle, applications, impact, and future prospective. In Sustainable Food Processing and Engineering Challenges; Elsevier: Amsterdam, The Netherlands, pp. 75–108.
Khanal, S.N. and Lucey, J.A. 2018. Effect of fermentation temperature on the properties of exopolysaccharides and the acid gelation behavior for milk fermented by Streptococcus thermophilus strains DGCC7785 and St-143. Journal of Dairy Science https://doi.org/10.3168/jds.2017-13203
Khatoon, H. and Najam, R. 2017. Bioactive components in camel milk: Their nutritive value and therapeutic application. In Nutrients in Dairy and Their Implications for Health and Disease. https://doi.org/10.1016/B978-0-12-809762-5.00029-2
Khedkar, C.D., Kalyankar, S.D. and Deosarkar, S.S. 2016. Fermented foods: Fermented milks. In Caballero, B., Finglas, P.M. and Toldrá, F. (Eds.), Encyclopedia of Food and Health (pp. 661–667). Academic Press. https://doi.org/10.1016/B978-0-12-384947-2.00286-5
Kholif, A.E., Morsy, T.A. and Abdo, M.M. 2018. Crushed flaxseed versus flaxseed oil in the diets of Nubian goats: Effect on feed intake, digestion, ruminal fermentation, blood chemistry, milk production, milk composition and milk fatty acid profile. Animal Feed Science and Technology 244: 66–75. https://doi.org/10.1016/j.anifeedsci.2018.08.003
Kizzie-Hayford, N., Jaros, D., Zahn, S. and Rohm, H. 2016. Effects of protein enrichment on the microbiological, physicochemical and sensory properties of fermented tiger nut milk. LWT–Food Science and Technology 74: 319–324. https://doi.org/10.1016/j.lwt.2016.07.067
Klein, T., Eckhard, U., Dufour, A., Solis, N. and Overall, C.M. 2018. Proteolytic cleavage mechanisms, function, and “omic” approaches for a near-ubiquitous posttranslational modification. Chemical Reviews, 118(3): 1137–1168.
Kok, C.R. and Hutkins, R. 2018. Yogurt and other fermented foods as sources of health-promoting bacteria. Nutrition Reviews 76: 4–15.
Kongo, J.M. and Malcata, F.X. 2015. Acidophilus milk. In Encyclopedia of Food and Health. https://doi.org/10.1016/B978-0-12-384947-2.00002-7
Koutinas, A.A. 2017. 1—Fermented dairy products. In Pandey, A., Sanromán, M.Á., Du, G., Soccol, C.R. and Dussap, C.G. (Eds.), Current Developments in Biotechnology and Bioengineering (pp. 3–24). Elsevier. https://doi.org/10.1016/B978-0-444-63666-9.00001-7
Krunic, T., Rakin, M., Bulatovic, M. and Zaric, D. 2018. Chapter 9—The contribution of bioactive peptides of whey to quality of food products. In Grumezescu, A.M. and Holban, A.M. (Eds.), Food Processing for Increased Quality and Consumption (pp. 251–285). Academic Press. https://doi.org/10.1016/B978-0-12-811447-6.00009-6.
László, N., Lányi, K. and Laczay, P. 2018. LC-MS study of the heat degradation of veterinary antibiotics in raw milk after boiling. Food Chemistry 267: 178–186. https://doi.org/10.1016/j.foodchem.2017.11.041
Leroy F, and De Vuyst L. 2022. Lactic acid bacteria as functional starter cultures for the food fermentation industry. Trends Food Sci Technol. 124:1–12. https://doi.org/10.1016/j.tifs.2003.09.004
Li, D., Peng, J., Kwok, L.Y., Zhang, W. and Sun, T. 2022. Metabolomic analysis of Streptococcus thermophilus S10-fermented milk. Lebensmittel-Wissenschaft & Technologie 161: 113368. https://doi.org/10.1016/J.LWT.2022.113368
Li, Y., Ma, Q., Li, M., Liu, W., Liu, Y., Wang, M., Wang, C. and Khan, M.Z., 2025. Non-bovine milk as functional foods with focus on their antioxidant and anti-inflammatory bioactivities. Antioxidants, 14(7), p.801.
Licitra, G., Caccamo, M. and Lortal, S. 2019. Chapter 9—Artisanal products made with raw milk. In Nero, L.A. and De Carvalho, A.F. (Eds.), Raw Milk (pp. 175–221). Academic Press. https://doi.org/10.1016/B978-0-12-810530-6.00009-2
Liu, F., Chen, Z., Shao, J., Wang, C. and Zhan, C. 2017. Effect of fermentation on the peptide content, phenolics and antioxidant activity of defatted wheat germ. Food Bioscience 20: 141–148. https://doi.org/10.1016/j.fbio.2017.10.002
Lopes de Oliveira, F., YankaPortes Arruda, T., CaldeiraMorzelle, M., Paula Aparecida Pereira, A. and Neves Casarotti, S. 2022. Fruit by-products as potential prebiotics and promising functional ingredients to produce fermented milk. Food Research International, 111841. https://doi.org/10.1016/J.FOODRES.2022.111841
Lorenzen, P.C. and Meisel, H. 2005. Influence of trypsin action in yoghurt milk on the release of caseinophosphopeptide-rich fractions and physical properties of the fermented products. International Journal of Dairy Technology 58:119–124. https://doi.org/10.1111/j.1471-0307.2005.00195.
Lucey, J.A. 2016. Raw milk consumption: Risks and benefits. Nutrients 8(6): 375. https://doi.org/10.3390/nu8060375.
Macuamule, C.L.S., Wiid, I.J., van Helden, P.D., Tanner, M. andWitthuhn, R.C. 2016. Effect of milk fermentation by kefir grains and selected single strains of lactic acid bacteria on the survival of Mycobacterium bovis BCG. International Journal of Food Microbiology 217: 170–176. https://doi.org/10.1016/j.ijfoodmicro.2015.10.024
Marco, M.L., Heeney, D., Binda, S., Cifelli, C.J., Cotter, P.D., Foligné, B., Gänzle, M., Kort, R., Pasin, G., Pihlanto, A., Smid, E.J. and Hutkins, R. 2017. Health benefits of fermented foods: Microbiota and beyond. In Current Opinion in Biotechnology. https://doi.org/10.1016/j.copbio.2016.11.010
Marco, M.L., Sanders, M.E., Gänzle, M., Arrieta, M.C., Cotter, P.D., De Vuyst, L., Hill, C., Holzapfel, W., Lebeer, S., Merenstein, D. and Reid, G., 2021. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on fermented foods. Nature Reviews Gastroenterology & Hepatology, 18(3), pp.196-208. https://doi.org/10.1038/s41575-020-00390-5
Martinez-Villaluenga, C., Peñas, E. and Frias, J. 2016. Bioactive peptides in fermented foods: Production and evidence for health effects. In Fermented Foods in Health and Disease Prevention. https://doi.org/10.1016/B978-0-12-802309-9.00002-9
Mati, A., Senoussi-Ghezali, C., Si Ahmed Zennia, S., Almi-Sebbane, D., El-Hatmi, H. and Girardet, J.M. 2017. Dromedary camel milk proteins, a source of peptides having biological activities—A review. In International Dairy Journal. https://doi.org/10.1016/j.idairyj.2016.12.001
Meucci, A., Rossetti, L., Zago, M., Monti, L., Giraffa, G., Carminati, D. and Tidona, F. 2018. Folates biosynthesis by Streptococcus thermophilus during growth in milk. Food Microbiology 69: 116–122. https://doi.org/10.1016/j.fm.2017.08.001
Meleti, E., Koureas, M., Manouras, A., Giannouli, P., and Malissiova, E. 2025. Bioactive Peptides from Dairy Products: A Systematic Review of Advances, Mechanisms, Benefits, and Functional Potential. Dairy, 6(6), 65. https://doi.org/10.3390/dairy6060065
Meyer A.L., Elmadfa I., Herbacek I., Micksche M. 2007. Probiotic, as well as conventional yogurt, can enhance the stimulated production of proinflammatory cytokines. Journal of Human Nutrition and Dietetics. 20 590–598. 10.1111/j.1365-277X.2007.00807.x [DOI
Milard, M., Laugerette, F., Durand, A., Buisson, C., Meugnier, E. and Loizon, E. 2019. Milk polar lipids in a high-fat diet can prevent body weight gain: modulated abundance of gut bacteria in relation with fecal loss of specific fatty acids. Molecular Nutrition & Food Research 63: e1801078. https://doi.org/10.1002/mnfr.201801078.
Miraghajani, M., Pourmasoumi, M. and Ghiasvand, R. 2017. Chapter 24—Dairy as a functional food in cardiovascular disease. In Watson, R.R., Collier, R.J. and Preedy, V.R. (Eds.), Nutrients in Dairy and their Implications on Health and Disease (pp. 313–324). Academic Press. https://doi.org/10.1016/B978-0-12-809762-5.00024-3
Mituniewicz-Małek, A., Ziarno, M., Dmytrów, I. and Balejko, J. 2017. Short communication: Effect of the addition of Bifidobacterium monocultures on the physical, chemical, and sensory characteristics of fermented goat milk. Journal of Dairy Science 100(9): 6972–6979. https://doi.org/10.3168/jds.2017-12818
Mohanty, D.P., Mohapatra, S., Misra, S. and Sahu, P.S. 2016b. Milk derived bioactive peptides and their impact on human health—A review. In Saudi Journal of Biological Sciences. https://doi.org/10.1016/j.sjbs.2015.06.005
Mohanty, D., Jena, R., Choudhury, P.K., Pattnaik, R., Mohapatra, S. and Saini, M.R. 2016a. Milk derived antimicrobial bioactive peptides: A review. International Journal of Food Properties 19:837–846. https://doi.org/10.1080/10942912.2015.1048356.
Mora, L., Aristoy, M.C. and Toldrá, F. 2019. Bioactive peptides. In Melton, L., Shahidi, F. Varelis, P. (Eds.), Encyclopedia of Food Chemistry (pp. 381–389). Academic Press. https://doi.org/10.1016/B978-0-08-100596-5.22397-4
Moreno-Montoro, M., Olalla-Herrera, M., Rufián-Henares, J.Á. Martínez, R.G., Miralles, B., Bergillos, T., Navarro-Alarcón, M. and Jauregi, P. 2017. Antioxidant, ACE-inhibitory and antimicrobial activity of fermented goat milk: Activity and physicochemical property relationship of the peptide components. Food and Function. https://doi.org/10.1039/c7fo00666g
Mudgal, S.P. and Prajapati, J.B. 2017. Chapter 20—Dahi—An Indian naturally fermented yogurt. In Yogurt in Health and Disease Prevention. https://doi.org/10.1016/B978-0-12-805134-4.00020-1
Mukherjee, A., Gomez-Sala, B., O’Connor, E.M., Kenny, J.G. and Cotter, P.D. 2022. Global regulatory frameworks for fermented foods: A review. Frontiers in Nutrition 9: 902642.
Narvhus, J.A. and Abrahamsen, R.K. 2023. Traditional and modern Nordic fermented milk products: A review. International Dairy Journal 142: 105641
Ni, H., Hayes, H.E., Stead, D. and Raikos, V. 2018. Incorporating salal berry (Gaultheria shallon) and blackcurrant (Ribes nigrum) pomace in yogurt for the development of a beverage with antidiabetic properties. Heliyon 4(10): e00875. https://doi.org/10.1016/j.heliyon.2018.e00875
Niaz, B., Saeed, F., Ahmed, A., Imran, M., Maan, A.A., Khan, M.K.I. and Suleria, H.A.R. 2019. Lactoferrin (LF): A natural antimicrobial protein. International Journal of Food Properties 22:1626–1641. 10.1080/10942912.2019.1666137
Nibbering, P.H., Ravensbergen, E., Welling, M.M., Van Berkel, L.A., van Berkel, P.H.C., Pauwels, E.K.J. and Nuijens, J.H. 2001. Human lactoferrin and peptides derived from its N terminus are highly effective against infections with antibiotic-resistant bacteria. Infection and Immunity 69:1469–1476. https://doi.org/10.1128/IAI.69.3.1469-1476.2001.
Nielsen, S.D., Beverly, R.L., Qu, Y. and Dallas, D.C. 2017. Milk bioactive peptide database: A comprehensive database of milk protein-derived bioactive peptides and novel visualization. Food Chemistry. 232: 673–682. https://doi.org/10.1016/j.foodchem.2017.04.056
Niyigaba, T., Kucukgoz, K., Kołoz˙yn-Krajewska, D., Krolikowski, T. and Trza˛skowska, M. 2025. Advances in fermentation technology: A focus on health and safety. Applied Sciences 15: 3001. https://doi.org/10.3390/app15063001
Nongonierma, A.B. and FitzGerald, R.J. 2015. The scientific evidence for the role of milk protein-derived bioactive peptides in humans: A review. Journal of Functional Foods. 17: 640–656. https://doi.org/10.1016/j.jff.2015.06.021
Nuñez, M. 2016. Existing technologies in non-cow milk processing and traditional non-cow milk products. In Non-Bovine Milk and Milk Products. https://doi.org/10.1016/B978-0-12-803361-6.00007-7
O’Callaghan, Y.C., Shevade, A.V., Guinee, T.P., O’Connor, T.P. and O’Brien, N.M. 2019. Comparison of the nutritional composition of experimental fermented milk: Wheat bulgur blends and commercially available kishk and tarhana products. Food Chemistry. 278: 110–118. https://doi.org/10.1016/j.foodchem.2018.11.026
O'callaghan, A. and Van Sinderen, D., 2016. Bifidobacteria and their role as members of the human gut microbiota. Frontiers in microbiology, 7, p.925. doi: 10.3389/fmicb.2016.00925
O'Connor, S., Greffard, K., Leclercq, M., Julien, P., Weisnagel, S.J. and Gagnon, C. 2019. Increased dairy product intake alters serum metabolite profiles in subjects at risk of developing type 2 diabetes. Molecular Nutrition & Food Research 63:e1900126. https://doi.org/10.1002/mnfr.201900126.
Ohshima, T. and Giri, A. 2014. Fermented foods: Traditional fish fermentation technology and recent developments. In Encyclopedia of Food Microbiology: Second Edition. https://doi.org/10.1016/B978-0-12-384730-0.00117-8
Ortiz-Rivera, Y., Sánchez-Vega, R., Gutiérrez-Méndez, N., León-Félix, J., Acosta-Muñiz, C. and Sepulveda, D.R. 2017. Production of reuterin in a fermented milk product by Lactobacillus reuteri: Inhibition of pathogens, spoilage microorganisms, and lactic acid bacteria. Journal of Dairy Science 100(6): 4258–4268. https://doi.org/10.3168/jds.2016-11534
Owusu-Kwarteng, J., Akabanda, F., Johansen, P., Jespersen, L. and Nielsen, D.S. 2017. Nunu, a West African fermented yogurt-like milk product. In Yogurt in Health and Disease Prevention. https://doi.org/10.1016/B978-0-12-805134-4.00015-8
Ozaybi, N. 2024. High-pressure processing of milk and dairy products: Latest update. Processes 12(10): 2073. https://doi.org/10.3390/pr12102073
Özer, B. and Kirmaci, H.A. 2014. Fermented milks: Products of Eastern Europe and Asia. In Encyclopedia of Food Microbiology: Second Edition. https://doi.org/10.1016/B978-0-12-384730-0.00123-3
Ozturkoglu-Budak, S. 2017. Beneficial and toxic compounds released by starter and secondary microbiota in dairy products. In Nutrients in Dairy and Their Implications for Health and Disease. https://doi.org/10.1016/B978-0-12-809762-5.00026-7
Pan, D.D., Wu, Z., Peng, T., Zeng, X.Q. and Li, H. 2014. Volatile organic compounds profile during milk fermentation by Lactobacillus pentosus and correlations between volatiles flavor and carbohydrate metabolism. Journal of Dairy Science 97(2): 624–631. https://doi.org/10.3168/jds.2013-7131
Panahipour, L., Stähli, A., Haiden, N. and Gruber, R. 2018. TGF-β activity in cow milk and fermented milk products: An in vitro bioassay with oral fibroblasts. Archives of Oral Biology 95: 15–21.https://doi.org/10.1016/j.archoralbio.2018.07.005
Papatheodorou, S. 2019. Umbrella reviews: What they are and why we need them. European Journal of Epidemiology 34:543–546. https://doi.org/10.1007/s10654-019-00505-6.
Park, Y.W. and Nam, M.S. 2015. Bioactive peptides in milk and dairy products: A review. Korean Journal for Food Science of Animal Resources 35:831–840. https://doi.org/10.5851/kosfa.2015.35.6.831.
Parodi, P.W. 1997. Cows’ milk fat components as potential anticarcinogenic agents. Journal of Nutrition 127:1055–1060. https://doi.org/10.1093/jn/127.6.1055.
Perin, L.M., Pereira, J.G., Bersot, L.S. and Nero, L. A. 2019. Chapter 3—The microbiology of raw milk. In Nero, L.A. and De Carvalho, A.F. (Eds.), Raw Milk (pp. 45–64). Academic Press. https://doi.org/10.1016/B978-0-12-810530-6.00003-1
Pothuraju, R., Yenuganti, V.R., Hussain, S.A. and Sharma, M. 2018. Fermented milk in protection against inflammatory mechanisms in obesity. In Immunity and Inflammation in Health and Disease. https://doi.org/10.1016/B978-0-12-805417-8.00029-9.
Pranckute, R., Kaunietis, A. and Kuisiene, N. 2014. Development of synbiotics with inulin, palatinose, alpha-cyclodextrin and probiotic bacteria. Polish Journal of Microbiology 63(1): 33–41.
Pranckutė, R., Kaunietis, A. and Kuisienė, N. 2016. Combining prebiotics with probiotic bacteria can enhance bacterial growth and secretion of bacteriocins. International Journal of Biological Macromolecules 89: 669–76.
Puvaca, N. and Vapa, B. 2024. Implementation of food safety policy in the European Union-guidance, variety, and resolution of challenges. Law Theory and Practice 41: 18.
Quinteri, L., Pistillo. P.B., Caputo, L., Favia, P. and Baruzzi, F. 2013. Bovine lactoferrin and lactoferricin on plasma-deposited coating against spoilage Pseudomonas spp. Innovative Food Science and Emerging Technologies 20:215–222. https://doi.org/10.1016/j.ifset.2013.04.013.
Ramos, I.M. and Poveda, J.M. 2022. Fermented sheep’s milk enriched in gamma-amino butyric acid (GABA) by the addition of lactobacilli strains isolated from different food environments. Lebensmittel-Wissenschaft & Technologie 163: 113581. https://doi.org/10.1016/J.LWT.2022.113581
Renhe, I.R.T., Perrone, Í.T., Tavares, G.M., Schuck, P. and de Carvalho, A.F. 2019. Chapter 2— Physicochemical characteristics of raw milk. In Nero, L.A. and De Carvalho, A.F. (Eds.), Raw Milk (pp. 29–43). Academic Press. https://doi.org/10.1016/B978-0-12-810530-6.00002-X
Ryu, J.A., Kim, E., Yang, S.M., Lee, S., Yoon, S.R., Jang, K.S. and Kim, H.Y. 2021. High-throughput sequencing of the microbial community associated with the physicochemical properties of Meju (dried fermented soybean) and Doenjang (traditional Korean fermented soybean paste). Lebensmittel-Wissenschaft & Technologie 146: 111473.
Sadauskaite-Kuehne, V., Ludvigsson, J. and Padaiga, Z. 2004. Longer breastfeeding is an independent protective factor against development of type 1 diabetes mellitus in childhood. Diabetes/Metabolism Research and Reviews 20: 150–157.
Saha, A., Oanca, G., Mondal, D. and Warshel, A. 2020. Exploring the proteolysis mechanism of the proteasomes. The Journal of Physical Chemistry B 124(27): 5626–5635.
Saleem, G.N., Gu, R., Qu, H., Bahar Khaskheli, G., Rashid Rajput, I., Qasim, M. and Chen, X. 2024. Therapeutic potential of popular fermented dairy products and its benefits on human health. Frontiers in Nutrition 11: 1328620.
Şanlier, N., Gökcen, B.B. and Sezgin, A.C. 2017. Health benefits of fermented foods. Critical Reviews in Food Science and Nutrition 25: 1–22.
Savilahti, E. and Saarinen, K.M. 2009. Early infant feeding and type 1 diabetes. European Journal of Nutrition 48: 243–249.
Shan-Shan, S., Na, Z. and Qing-Zhang, L. 2016. Effect of different roughages on milk protein and milk fat synthesis in dairy cows. Journal of Northeast Agricultural University (English Edition) 23(4): 40–46. https://doi.org/10.1016/S1006-8104(17)30005-3
Shuang, W., Zeng, X., Li, T., Li, J., Sun, Q., & Chen, L. (2026). Screening, Safety Assessment, and Process Optimization of Lactic Acid Bacteria from Traditional Yak Yogurt as Adjunct Cultures. Microorganisms, 14(3), 630. https://doi.org/10.3390/microorganisms14030630
Singh, B., Ram, C., Singh, D., Singh, N.P., Singh, A., Singh, R. and Verma, R.R. 2018. Chapter 14—Potential of novel bioactive peptides as functional food ingredients in preventing cardiovascular disease. In Holban, A.M. and Grumezescu, A.M. (Eds.), Alternative and Replacement Foods (pp. 411–431). Academic Press. https://doi.org/10.1016/B978-0-12-811446-9.00014-9
Silva, C.C., Silva, S.P. and Ribeiro, S.C., 2018. Application of bacteriocins and protective cultures in dairy food preservation. Frontiers in microbiology, 9, p.594. https://doi.org/10.3389/fmicb.2018.00594
Smid, E.J. and Lacroix, C., 2013. Microbe–microbe interactions in mixed culture food fermentations. Current opinion in biotechnology, 24(2), pp.148-154 https://doi.org/10.1016/j.copbio.2012.11.007
Song A.A.L., In L.L., Lim S.H.E., Rahim R.A. A review on Lactococcus lactis: From food to factory. Microbial Cell Factories. 2017;16:1–15.
Song P., Zhang, X., Wang, S., Xu, W., Wang, F., Fu, R. and Wei, F. 2023. Microbial proteases and their applications. Frontiers in Microbiology 14: 1236368. https://doi.org/10.3389/fmicb.2023.1236368. PMID: 37779686; PMCID: PMC10537240
Sultan, S., Huma, N., Butt, M.S., Aleem, M. and Abbas, M. 2018. Therapeutic potential of dairy bioactive peptides: a contemporary perspective. Critical Reviews in Food Science and Nutrition 58:105–115. https://doi.org/10.1080/10408398.2015.1136590.
Swelum, A. A., El-Saadony, M. T., Abdo, M., Ombarak, R. A., Hussein, E. O. S., Suliman, G., Alhimaidi, A. R., Ammari, A. A., Ba-Awadh, H., Taha, A. E., El-Tarabily, K. A., and Abd El-Hack, M. E. 2021. Nutritional, antimicrobial and medicinal properties of Camel's milk: A review. Saudi journal of biological sciences, 28(5), 3126–3136. https://doi.org/10.1016/j.sjbs.2021.02.057
Tamang, J.P. 2009. Himalayan fermented foods: microbiology, nutrition, and ethnic values. CRC press.
Tan, Y.Q., Ong, H.C., Yong, A.M.H., Fattori, V. and Mukherjee, K. 2024. Addressing the safety of new food sources and production systems. Comprehensive Reviews in Food Science and Food Safety 23: e13341.
Tanaka, S., Yoneoka, D., Ishizuka, A., Adachi, M., Hayabuchi, H., Nishimura, T., Takemi, Y., Uneyama, H., Nakamura, H. and Lwin, K.S. 2023. Modelling of salt intake reduction by incorporation of umami substances into Japanese foods: A cross-sectional study. BMC Public Health 23: 516.
Tavares, T. and Malcata, F. X. 2019. Chapter 10—Alternative dairy products made with raw milk. In Nero, L.A. and De Carvalho, A.F. (Eds.), Raw Milk (pp. 223–234). Academic Press. https://doi.org/10.1016/B978-0-12-810530-6.00010-9
Teneva-Angelova, T., Hristova, I., Pavlov, A. and Beshkova, D. 2018. Lactic acid bacteria-from Nature through food to health. In Advances in Biotechnology for Food Industry. https://doi.org/10.1677/JOE-06-0081
Terefe, N.S. 2016. Food fermentation. In Reference Module in Food Sciences. Werribee, Australia: Elsevier. https://doi.org/10.1016/B978-0-08-100596-5.03420-X
Toldrá, F., Reig, M., Aristoy, M. C. and Mora, L. 2018. Generation of bioactive peptides during food processing. Food Chemistry. 267: 395–404. https://doi.org/10.1016/j.foodchem.2017.06.119
Tonello-Samson, C., Queirós, R.P. and González-Angulo, M. (2020). Advances in high-pressure processing in-pack and in-bulk commercial equipment. In Present and Future of High Pressure Processing; Elsevier: Amsterdam, The Netherlands, pp. 297–316.
Tripathi R. and Nair N.N. 2013 Oct. Mechanism of acyl-enzyme complex formation from the Henry-Michaelis complex of class C β-lactamases with β-lactam antibiotics. Journal of the American Chemical Society 2;135(39):14679–90. https://doi.org/10.1021/ja405319n. Epub 2013 Sep 23. PMID: 24010547.
Tunick, M.H. and Van Hekken, D.L. 2015. Dairy products and health: Recent insights. Journal of Agricultural and Food Chemistry 63(43): 9381–9388.
Turkmen, N., Akal, C. and Özer, B. 2019. Probiotic dairy-based beverages: A review. Journal of Functional Foods 53: 62–75. https://doi.org/10.1016/j.jff.2018.12.004
U.S. Department of Agriculture and U.S. Department of Health and Human Services. 2020. Dietary Guidelines for Americans, 2020–2025. 9th Edition. December 2020. Accessed January 05, 2026. Available at https://www.dietaryguidelines.gov/
Utz, V.E.M., Perdigón, G. and de Moreno de LeBlanc, A. 2017. Chapter 26—Fermented milks and cancer. In Watson, R.R., Collier, R.J. and Preedy, V.R. (Eds.), Dairy in Human Health and Disease Across the Lifespan (pp. 343–351). Academic Press. https://doi.org/10.1016/B978-0-12-809868-4.00026-1
Vaghela, K.D., Chaudhary, B.N. and Mehta, B.M. 2018. A review on proteolysis rate in UHT milk: Its mechanism, pattern, assessment, and enzymatic changes during storage. Research & Reviews: Journal of Dairy Science and Technology 6(3): 1–16.
Van Horn, L., Carson, J.A., Appel, L.J., Burke, L.E., Economos, C. and Karmally, W. 2016. Recommended dietary pattern to achieve adherence to the American Heart Association/American College of Cardiology (AHA/ACC) guidelines: A scientific statement from the American Heart Association. Circulation 134: e505–e529. https://doi.org/10.1161/CIR.0000000000000462.
Verruck, S., Dantas, A. and Prudencio, E.S. 2019. Functionality of the components from goat’s milk, recent advances for functional dairy products development and its implications on human health. Journal of Functional Foods 52: 243–257. https://doi.org/10.1016/j.jff.2018.11.017
Vieira, C.P., Cabral, C.C., da Costa Lima, B.R.C., Paschoalin, V.M.F., Leandro, K.C. and Conte-Junior, C.A. 2017. Lactococcus lactis ssp. cremoris MRS47, a potential probiotic strain isolated from kefir grains, increases cis-9, trans-11-CLA and PUFA contents in fermented milk. Journal of Functional Foods 31, 172–178. https://doi.org/10.1016/j.jff.2017.01.047
von Mutius, Erika and Donata Vercelli. 2010. Farm living: Effects on childhood asthma and allergy. Nature Reviews Immunology 10: 861–868.
Wache, Y., Do, T.L., Do, T.B.H., Do, T.Y., Haure, M., Ho, P.H., Kumar Anal, A., Le, V.V.M., Li, W.J. and Licandro, H. 2018. Prospects for food fermentation in South-East Asia, topics from the tropical fermentation and biotechnology network at the end of the AsiFood Erasmus+Project. Frontiers in Microbiology 9: 2278.
Walsh, A.M., Crispie, F., Claesson, M.J. and Cotter, P.D., 2017. Translating omics to food microbiology. Annual Review of Food Science and Technology, 8(1), pp.113-134. https://doi.org/10.1146/annurev-food-030216-025729
Walstra, P., Wouters, J.T.M. and Geurts, T.J. 2006. Dairy Science and Technology (2nd ed.). CRC Press.
Wang, J., Li, C., Xue, J., Yang, J., Zhang, Q., Zhang, H. and Chen, Y. 2015. Fermentation characteristics and angiotensin I-converting enzyme–inhibitory activity of Lactobacillus helveticus isolate H9 in cow milk, soy milk, and mare milk. Journal of Dairy Science 98(6): 3655–3664. https://doi.org/10.3168/jds.2015-9336
Wang, X., Sun, Y., Wang, F., You, L., Cao, Y., Tang, R. and Cui, X. 2020. A novel endogenous antimicrobial peptide CAMP 211–225 derived from casein in human milk. Food & Function 11: 2291–2298. https://doi.org/10.1039/c9fo02813g.
Wang, Y., Feng, K., Jin, J., Safian Murad, M., Mu, G. and Wu, X. 2022. Comparison on properties between normal and A2 bovine milk fermented using commercial bacteria mixed with/without two probiotics from human milk. International Journal of Biological Macromolecules 216: 105–113. https://doi.org/10.1016/J.IJBIOMAC.2022.06.200
Weinstein, E. 2025. Outbreak of Salmonella Typhimurium infections linked to commercially distributed raw milk—California and four other states, September 2023–March 2024. MMWR 74. https://www.cdc.gov/mmwr/volumes/74/wr/mm7427a1.htm
Wernery, U. 2006. Camel milk, the white gold of the desert. Journal of Camel Practice and Research 13(1): 15.
Wichansawakun, S. and Buttar, H.S. 2019. Antioxidant diets and functional foods promote healthy aging and longevity through diverse mechanisms of action. In The Role of Functional Food Security in Global Health. https://doi.org/10.1016/B978-0-12-813148-0.00032-3
Wilburn, J.R. and Ryan, E.P. 2016. Fermented foods in health promotion and disease prevention: An overview. In Fermented Foods in Health and Disease Prevention. https://doi.org/10.1016/B978-0-12-802309-9.00001-7
Woldemariam, H.W. and Emire, S. A. 2019. High pressure processing of foods for microbial and mycotoxins control: Current trends and future prospects. Cogent Food & Agriculture 5: 1622184.
World Health Organization European Region. (2003). Food based dietary guidelines in the WHO European Region. Copenhagen: WHO, Europe.
Wouters, J.T., Ayad, E.H., Hugenholtz, J. and Smit, G. 2002. Microbes from raw milk for fermented dairy products. International Dairy Journal 12(2–3): 91–109.
Wu, Z., Wu, J., Cao, P., Jin, Y., Pan, D., Zeng, X. and Guo, Y. 2017. Characterization of probiotic bacteria involved in fermented milk processing enriched with folic acid. Journal of Dairy Science 100(6): 4223–4229. https://doi.org/10.3168/jds.2017-12640
Yahya, M.A., Alhaj, O.A. and Al-Khalifah, A.S. 2017. Antihypertensive effect of fermented skim camel (Camelus dromedarius) milk on spontaneously hypertensive rats. NutricionHospitalaria 34(2): 416–421. https://doi.org/10.20960/nh.1163
Yang, S., Bai, M., Kwok, L.Y., Zhong, Z. and Sun, Z. 2025. The intricate symbiotic relationship between lactic acid bacterial starters in the milk fermentation ecosystem. Critical Reviews in Food Science and Nutrition 65(4): 728–745.
Yılmaz, B. and Tosun, H. 2013. Natural antimicrobial systems in milk and their use in the food industry—the natural antimicrobial systems in milk and their utilization in food industry. Celal Bayar University Journal of Science 9: 11–20.
Zhang, X., Chen, X., Xu, Y., Yang, J., Du, L., Li, K. and Zhou, Y. 2021. Milk consumption and multiple health outcomes: Umbrella review of systematic reviews and meta-analyses in humans. Nutrition & Metabolism (Lond) 7(18): 7. https://doi.org/10.1186/s12986-020-00527-y
Zhao, C. J., Schieber, A. and Gänzle, M.G. 2016. Formation of taste-active amino acids, amino acid derivatives and peptides in food fermentations–A review. In Food Research International. https://doi.org/10.1016/j.foodres.201,6.08.042
